Immunoglobulin heavy variable 3-6 (pseudogene) (IGHV3-6)

Immunoglobulin heavy variable 3-6 (IGHV3-6) is classified as a pseudogene within the immunoglobulin heavy variable gene family, located in the human IGH locus on chromosome 14q32.33[3][6]. Pseudogenes in this region are non-functional gene segments that do not encode a protein product and are not involved in the generation of antibody diversity or immune receptor structure in humans[3][4]. They arise through gene duplication or mutation events and are characterized by features such as premature stop codons or frame-shift mutations, which prevent their expression as functional immunoglobulin variable regions. As IGHV3-6 is a pseudogene, it plays no direct biological or therapeutic role and is not considered a druggable or therapeutic target[3][6][4].

Other names

3-06PIGHV36IGHV3-6