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Immunoglobulin heavy variable 3-74 (IGHV3-74)
- Target
- IGHV3-74
- Molecular classification
- Immunoglobulin variable region gene, Other (falls under immunoglobulin gene family—specifically, heavy chain V (variable) segment)
01
Overview
Immunoglobulin heavy variable 3-74 is a gene segment located on chromosome 14, encoding part of the variable region of the heavy chain in immunoglobulins (antibodies). It contributes to the diversity of the antigen-binding site through V(D)J recombination during B cell development. The protein product is not a standalone receptor or target, but combines with other immunoglobulin segments and the light chain to form the antigen recognition portion of antibodies responsible for the specificity of the adaptive immune response. Extensive allelic polymorphism among IGHV genes, including IGHV3-74, contributes to the diversity and efficacy of human antibody responses.
- Other names
- IGHV3-74IGHV374Immunoglobulin heavy variable 3-74Immunoglobulin heavy chain variable regionVH (variable region, heavy chain)
02
Biological functions
Antigen recognitionAdaptive immune response (humoral immunity)Antigen binding activity
03
Disease associations
Other (IGHV polymorphisms can influence immune response variability and susceptibility to certain infections or immune conditions, but IGHV3-74 itself is not directly implicated in specific diseases as a standalone gene)
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