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Target intelligence / Profile preview
Immunoglobulin Heavy Variable 4–34 (IGHV4-34)
- Target
- IGHV4-34
- Molecular classification
- Immunoglobulin, B cell receptor component
01
Overview
Immunoglobulin Heavy Variable 4–34 (IGHV4-34) encodes part of the variable region of the immunoglobulin heavy chain, crucial for antigen recognition. It functions in antigen binding and mediates adaptive immune responses. Its expression on malignant B cells in various lymphomas makes it a target for precision therapies like CAR-T cell therapy.
- Other names
- IGHV434VH
02
Mechanism of action
Targeting IGHV4-34 expressing B cells with CAR-T cell therapy.
03
Biological functions
Antigen bindingAdaptive immune responseImmunoglobulin-mediated immune response
04
Disease associations
Diffuse Large B-Cell Lymphoma (DLBCL)Primary Central Nervous System LymphomaVitreoretinal LymphomaHairy Cell LeukemiaChronic Lymphocytic Leukemia
05
Safety considerations
Off-target effects on normal B cells (though minimized due to low expression in normal B cells)
06
Biomarkers
IGHV4-34 expression in malignant B cells
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