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Target intelligence / Profile preview
Immunoglobulin Heavy Variable 4-34 (IGHV4-34)
- Target
- IGHV4-34
- Molecular classification
- Immunoglobulin, B cell receptor component, Variable region segment
01
Overview
The immunoglobulin heavy variable 4-34 (IGHV4-34) gene encodes a variable region of the immunoglobulin heavy chain, a critical component of the B cell receptor (BCR) on B lymphocytes. This gene segment is notable for its intrinsic self-reactivity, particularly against I/i carbohydrate antigens, and its involvement in both protective immunity and autoimmune disease. While normally tightly regulated to prevent autoreactivity, dysregulation of IGHV4-34 expressing B cells can contribute to the pathogenesis of diseases like SLE and cold agglutinin disease. It also plays a role in certain B cell malignancies like hairy cell leukemia and CLL.
- Other names
- VH4-34VH4-21
02
Mechanism of action
N/A
03
Biological functions
Antigen recognitionB cell receptor signalingImmune responseAutoantibody productionContainment of commensal bacteria (under certain conditions)
04
Disease associations
Hairy Cell LeukemiaChronic Lymphocytic LeukemiaSystemic Lupus ErythematosusCold Agglutinin DiseaseAutoimmunity
05
Safety considerations
Potential for autoreactivity and autoimmune disease developmentDysregulation can lead to pathogenic autoantibody production
06
Biomarkers
IGHV4-34 expression in B cells (diagnosis and prognosis in CLL)Serum levels of VH4-34 antibodies (monitoring autoimmune disease activity)
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