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Target intelligence / Profile preview
Immunoglobulin heavy variable 4-80 (IGHV4-80)
- Target
- IGHV4-80
- Molecular classification
- Other (Immunoglobulin variable region gene segment)
01
Overview
Immunoglobulin heavy variable 4-80 (IGHV4-80) refers to a gene segment encoding the variable region of the heavy chain of immunoglobulins (antibodies). These gene segments contribute to the diversity and specificity of antibodies by combining with diversity (D) and joining (J) segments during B-cell development, enabling antigen recognition as part of the adaptive immune response[1][2]. IGHV4-80 is not a direct drug target or therapeutic receptor; rather, it is part of the immunoglobulin locus that provides the genetic templates for the variable domain of immunoglobulin heavy chains. There is limited information on this particular gene segment, and it does not represent a canonical protein or receptor target but rather a DNA element used in antibody diversity.
- Other names
- IGHV4-804-80PIGHV480Immunoglobulin heavy variable 4-80
02
Biological functions
Immune responseAntigen recognition
03
Disease associations
Other (Components may be indirectly associated with diseases involving B-cell function and antibody repertoire abnormalities, but not a direct target)
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