Immunoglobulin heavy variable 7-4-1 (IGHV7-4-1)

Immunoglobulin heavy variable 7-4-1 (IGHV7-4-1) is a gene segment encoding a variable region of the immunoglobulin heavy chain, which is part of the antigen-binding site in human antibodies[1]. It participates in generating the diverse repertoire of antibodies produced by B lymphocytes through somatic recombination (V-(D)-J rearrangement), which is essential for the adaptive immune system’s ability to recognize a wide range of antigens[1][2]. IGHV7-4-1 is expressed at low levels compared to other immunoglobulin heavy variable genes and may have reduced capacity to produce functional products due to an unusual cysteine residue at position 92, potentially compromising the structure or stability of antibodies derived from this segment[2]. This gene is not a receptor, enzyme, or typical therapeutic target by itself, but rather a genetic element contributing to antibody diversity[1][2].

Other names

Immunoglobulin heavy variable-74-1IGHVII-74-1IGHV(II)-74-1