Immunoglobulin kappa constant (IGKC)

Immunoglobulin kappa constant is the constant domain of the kappa-type light chain of human antibodies, encoded by the IGKC gene. It forms part of the immunoglobulin molecule produced by B lymphocytes and does not participate in antigen binding directly, but stabilizes the antibody structure and supports antibody function in the immune response. The constant region is identical in all kappa light chains and is crucial for the effector functions of secreted antibodies in humoral immunity, such as antigen clearance and immune complex formation. Measurement of kappa light chains is clinically important as a marker for conditions like multiple myeloma and other B cell malignancies, but the IGKC itself does not serve as a direct therapeutic target

Other names

Immunoglobulin kappa constantIGKCHCAK1Ig kappa chain C regionIg kappa chain C region AGIg kappa chain C region CUMIg kappa chain C region EUIg kappa chain C region OUIg kappa chain C region ROYIg kappa chain C region TIIGKCDKmimmunoglobulin kappa (invariant region)immunoglobulin kappa constant regionimmunoglobulin kappa light chain (VJ)immunoglobulin κ light chainκ light chainIG κ constant

Not applicable (the constant region is not a direct target for drug action; mechanisms generally involve antigen binding by antibodies)