Immunoglobulin kappa joining 1 (IGKJ1)

Immunoglobulin kappa joining 1 (IGKJ1) is a gene segment located on chromosome 2p11.2, encoding the J region of the variable domain of immunoglobulin kappa light chains[3][4][5]. During B cell development, IGKJ1 participates in V-(D)-J recombination, contributing to the diversity of antibody antigen recognition sites[1][2][3]. As part of the immunoglobulin kappa locus, it helps form the junction between the variable and constant regions of the kappa light chain. IGKJ1 is not a protein that acts as a classical receptor, enzyme, or transporter; it is one of several joining segments involved in generating the mature immunoglobulin kappa light chain. The functional product is incorporated into the antigen-binding portion of antibodies but is not itself a direct target for pharmacological intervention[1][3][5].

Other names

IGKJ1J1Immunoglobulin kappa joining 1

Not applicable. Drugs do not target IGKJ1 directly.