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Target intelligence / Profile preview
Immunoglobulin Kappa Light Chain (κ light chain)
- Target
- κ light chain
- Molecular classification
- Immunoglobulin, Antibody Light Chain
01
Overview
The immunoglobulin kappa (κ) light chain is one of the two types of light chains found in antibodies. It participates in antigen recognition by forming part of the antigen-binding site along with heavy chain domains. Abnormal increases or imbalances can indicate plasma cell disorders such as multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), or primary amyloidosis. Some pathological variants show altered stability compared to non-pathogenic forms—certain disease-associated variants aggregate more readily under physiological conditions leading to tissue deposition and organ dysfunction.
- Other names
- Kappa Light ChainIg Kappa Light ChainK light chain
02
Mechanism of action
N/A
03
Biological functions
Antigen recognitionAntibody structureImmune response
04
Disease associations
Multiple MyelomaMonoclonal Gammopathy of Undetermined Significance (MGUS)AL AmyloidosisLight Chain Deposition DiseaseCancer
05
Safety considerations
Light chain deposition diseaseAmyloidosisRenal toxicity
06
Biomarkers
Free Kappa Light Chains (serum/urine)Kappa/Lambda ratio
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