Immunoglobulin kappa variable 1-22 (IGKV1-22)

Immunoglobulin kappa variable 1-22 (IGKV1-22) encodes the variable region of the kappa light chain in human antibodies.[1][2] As part of the immunoglobulin gene family, IGKV1-22 is one of many variable (V) gene segments that rearrange through somatic recombination in B cells to generate antibody diversity. The product of this gene forms the variable domain at the N-terminus of the kappa light chain, contributing to the antigen-binding site of immunoglobulins (antibodies).[1] IGKV1-22 itself does not encode a standalone receptor or enzyme, but acts as a component of antibodies expressed by B cells. Changes or polymorphisms in IGKV1-22 may impact the diversity of the humoral immune response but are not directly linked as therapeutic targets, biomarkers, or disease drivers.[1][2][3] Key context: - "Immunoglobulin kappa variable 1-22" is not itself a canonical drug target but is a genetic locus contributing to the variable region of antibodies.[2] - The gene is not implicated as a standalone biomarker, direct disease gene, or subject of therapeutic drug interventions. - IGKV1-22 may appear in studies of antibody gene usage or B-cell clonality analyses, but without direct actionable targeting.

Other names

IGKV1-22A25IGKV122IGK-V1-22