Immunoglobulin kappa variable 1-33 (IGKV1-33)

Immunoglobulin kappa variable 1-33 is part of the variable region of the human immunoglobulin kappa light chain, which, combined with the variable heavy chain domain, forms the antigen-binding site of antibodies. These regions are assembled by V-(D)-J recombination and can undergo somatic hypermutation, enabling affinity maturation in response to antigen exposure. Their primary function is to contribute to antigen recognition and diversity in humoral immunity, but as isolated domains, they are not therapeutic targets on their own. The requested target "immunoglobulin kappa variable 1/OR-2" is not a standard or recognized entry, and appears to be incorrect or misnamed. The closest validated targets are members of the immunoglobulin kappa variable family, e.g., IGKV1-33.

Other names

Ig kappa chain V-I region AUIg kappa chain V-I region KaKV133_HUMANP01594 (UniProt)IGKV1-33