Immunoglobulin kappa variable 1-35 (IGKV1-35)

Immunoglobulin kappa variable 1-35 (IGKV1-35) is a member of the IGKV (immunoglobulin kappa variable) gene family, which encodes the variable domain of the kappa light chains of antibodies. The variable (V) regions are responsible for antigen recognition and are generated by V-(D)-J recombination during B cell development. Each antibody has two light chains, with the variable region determining antigen specificity. These variable regions are not independent protein targets but gene segments that recombine to produce functional immunoglobulins. They are not considered therapeutic targets, receptors, or enzymes[3]. If IGKV1-35 is referenced, it likely refers to a gene segment involved in antibody diversity, not a standalone protein or conventional drug target. IGKV1-35 is part of a larger family including other segments such as IGKV1-33 and IGKV1-39, which have very similar structure and function as described in the literature[1][2][3]. The IGKV1-35 gene is not typically associated as a direct drug target, disease biomarker, or specific therapeutic concern. Instead, it contributes structurally and genetically to the diversity of the immunoglobulin repertoire. No evidence suggests IGKV1-35 is directly implicated in disease as a causative gene nor as a stand-alone biomarker[3]. Given the context and nomenclature, it's likely that use of "IGKV1-35" as a "target" is a misinterpretation; these are germline gene segments described as part of immunoglobulin structure, not a classic molecular target[3]. If structured information or specific target validation is required (such as for drug screening or mechanistic studies), the proper approach would be to reference the full immunoglobulin or its idiotype, not the germline segment itself.

Other names

IGKV1-35