Immunoglobulin kappa variable 1-39 (IGKV1-39)

Immunoglobulin kappa variable 1-39 (IGKV1-39) encodes the V (variable) region of the kappa light chain in immunoglobulins (antibodies)[5][10][3]. This region forms part of the antigen binding site and contributes molecular diversity through V(D)J recombination and somatic hypermutation, which are essential for adaptive immune response and specificity[5][10][3]. The variable region of the kappa light chain, paired with the variable region of the heavy chain, determines the specificity of antibody–antigen interactions. The IGKV1-39 gene is present in the genome but does not produce a functional protein by itself; rather, it contributes to antibody diversity in B-cells via genetic rearrangement mechanisms[2][5]. Various alternative names reflect historical isolates of immunoglobulin light chains with IGKV1-39 sequence characteristics, often associated with certain monoclonal gammopathies or as research reagents[2][5][9]. IGKV1-39 is not a druggable therapeutic target, enzyme, transporter, or receptor, but is a critical genetic component of antibody variable regions and crucial for humoral immunity[7][10][8].

Other names

Ig kappa chain V-I region DEEIg kappa chain V-I region HauIg kappa chain V-I region MevIg kappa chain V-I region OUIg kappa chain V-I region WalkerIGKV139O12O12aIGKV1-39KV139