Immunoglobulin kappa variable 1D-16 (IGKV1D-16)

Immunoglobulin kappa variable 1D-16 is the **variable region** of the kappa light chain in human antibodies[1][2][4][6]. It is involved in the **antigen recognition** phase of humoral immunity, where together with the immunoglobulin heavy chain variable region, it forms the specific antigen-binding site of antibodies produced by B lymphocytes. This region is encoded by a gene segment that undergoes somatic recombination (V-(D)-J rearrangement) and somatic hypermutation, promoting antibody diversity and affinity maturation[1][4]. IGKV1D-16 is not itself a therapeutic drug target (such as an enzyme, receptor, or transporter) but rather a gene segment contributing to the variability of antibodies used for antigen recognition in immune defense. **Notes:** - This entry defines a *gene segment* and its protein product as part of the antibody variable domain, not a classic receptor or therapeutic target[1][4][6]. - There are no drugs that specifically target IGKV1D-16, nor is it directly implicated as a disease-associated protein or biomarker. - While essential in *immune response*, its function is as a component of the immunoglobulin molecule rather than a standalone molecular target for drugs.

Other names

IGKV1D-16Ig kappa chain V-I region HK146Ig kappa chain V-I region HK189IGKV1D16L15L15a