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Target intelligence / Profile preview
Immunoglobulin kappa variable 1D-17 (IGKV1D-17)
- Target
- IGKV1D-17
- Molecular classification
- Immunoglobulin variable gene segment, Immunoglobulin family
01
Overview
Immunoglobulin kappa variable 1D-17 (IGKV1D-17) encodes the variable domain segment of immunoglobulin kappa light chains, which combine with heavy chains to form the antigen binding site of antibodies. This region is crucial for the specificity and diversity of antibody-mediated immune responses. IGKV1D-17 participates in antigen recognition by B cell receptors and contributes to the humoral immune response. It is one of many variable region gene segments generated by V-(D)-J rearrangement and somatic hypermutation, thus participating in the adaptive immune system’s ability to recognize diverse pathogens[1][5][7][3].
- Other names
- IGKV1D-17IGKV1D17L14Immunoglobulin kappa variable 1D-17
02
Biological functions
Antigen recognitionImmune responseComponent of the antigen binding site in antibodies
03
Disease associations
Other (Not associated specifically with cancer, infection, or other common therapeutic disease categories; variable regions can participate in immune responses including autoimmunity and infectious diseases via antibody diversity, but IGKV1D-17 itself is not designated as a disease gene)
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