Immunoglobulin kappa variable 1D-22 (IGKV1D-22)

Immunoglobulin kappa variable 1D-22 (IGKV1D-22) is a pseudogene that belongs to the immunoglobulin kappa light chain variable region gene family[2][4]. Immunoglobulin variable (V) genes, such as those in the IGKV family, normally participate in the generation of antibody diversity via V-(D)-J recombination in B lymphocytes, forming the variable region of antibodies which determines antigen specificity[3][5]. However, as a pseudogene, IGKV1D-22 does not encode a functional protein product and does not contribute directly to antigen binding or immune response[2][4]. It is primarily annotated in genomic and gene catalogs for reference in studies of immunoglobulin gene organization and evolution. There are no known drugs, direct disease roles, or biomarker uses associated with this pseudogene, and it is not considered a therapeutic target.

Other names

A9IGKV1D22IGKV1D-22