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Target intelligence / Profile preview
Immunoglobulin kappa variable 1D-27 (IGKV1D-27)
- Target
- IGKV1D-27
- Molecular classification
- Immunoglobulin variable region gene, Gene segment (not a receptor, enzyme, transporter, or ion channel), Immunoglobulin superfamily
01
Overview
Immunoglobulin kappa variable 1D-27 (IGKV1D-27) refers to a variable (V) region gene segment located in the distal segment of the immunoglobulin kappa light chain locus on chromosome 2p11.2. The gene segment encodes part of the variable domain of the kappa light chains in immunoglobulins, enabling B cells to generate diverse antigen-binding sites through V-J gene rearrangement and somatic hypermutation. IGKV1D-27 is not a receptor, enzyme, or classical therapeutic target; it is part of the genetic template for antibodies essential in adaptive immune response[2][3][5][10].
- Other names
- Immunoglobulin kappa variable 1D-27IGKV1D-27
02
Biological functions
Antigen recognition (as part of the kappa light chain of antibodies)Responsible for generating diversity in antibody specificity via V-J rearrangement in B cellsImmune response (as part of the adaptive humoral immunity)
03
Disease associations
Other (no direct disease association; alterations in immunoglobulin variable region genes can, in rare cases, contribute to immune disorders or be markers in certain lymphoid malignancies, but IGKV1D-27 itself is not specifically implicated)
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