Immunoglobulin kappa variable 1D-32 (pseudogene) (IGKV1D-32)

Immunoglobulin kappa variable 1D-32 (IGKV1D-32) is a pseudogene present in the distal portion of the immunoglobulin kappa (IGK) chain locus on chromosome 2, which harbors both functional variable region genes and pseudogenes. The IGK locus comprises both proximal and distal clusters, with distal genes identified by the "D" designation. Pseudogenes such as IGKV1D-32 do not encode functional variable region domains for kappa light chains and do not participate in antigen recognition or immune signaling. They may contribute to genetic diversity through gene conversion or recombination events but are not considered direct druggable therapeutic targets, nor do they encode protein products relevant for direct pharmacological intervention. The immunoglobulin kappa variable family includes both functional and non-functional (pseudogene) members; pseudogenes are prevalent in these complex gene clusters and can affect genetic studies or sequence alignments, but lack established roles in immune response, disease, or as drug targets. IGKV1D-32 specifically is catalogued as a pseudogene in multiple databases and product catalogues, indicating its lack of functional product.

Other names

IGKV1D32O9