Immunoglobulin kappa variable 1D-39 (IGKV1D-39)

Immunoglobulin kappa variable 1D-39 (IGKV1D-39) encodes the variable domain of the kappa light chain of immunoglobulins (antibodies). This region is critical for the formation of the antigen binding site, enabling the immune system to recognize and specifically bind diverse antigens. The variable region is assembled via V-(D)-J (variable-diversity-joining) recombination and undergoes somatic hypermutation to optimize affinity in the adaptive immune response. IGKV1D-39 is not a receptor or direct therapeutic drug target, but is a building block of the antibody repertoire. Its sequence can be incorporated into engineered monoclonal antibodies for therapeutic or diagnostic use. If direct drug interactions or abnormal safety concerns are needed, those would refer to the specific engineered antibody constructs—not the IGKV1D-39 germline gene itself. No drugs or therapeutic agents interact with IGKV1D-39 as an isolated molecular entity.

Other names

O2IGKV1D39KVD39Ig kappa chain V-I region DaudiIGKV1D-39

As part of engineered antibodies, enables antigen recognition and neutralization or signaling (mechanism depends on antibody construct, e.g., blockade, agonism, opsonization)