Immunoglobulin kappa variable 1D-42 (IGKV1D-42)

Immunoglobulin kappa variable 1D-42 (IGKV1D-42) is a predicted non-functional open reading frame (ORF) belonging to the immunoglobulin kappa variable (IGKV) gene family, encoding part of the variable domain of the immunoglobulin light chains[1][5]. Non-functional immunoglobulin variable genes such as IGKV1D-42 typically do not participate in the synthesis of productive immunoglobulin light chains, usually due to disrupted V-(D)-J or switch recombination, abnormal splicing, or critical amino acid changes at the protein level[1][5]. The IGKV genes, located at chromosome 2p11.2, comprise part of the immune system's gene repertoire and are normally involved in antigen binding through the variable domains of antibodies[3][4]. However, because IGKV1D-42 is identified as a probable non-functional or pseudogene locus, it does not encode a functional protein to participate in immune response[1][5]. This gene is not considered a direct therapeutic target, disease biomarker, or druggable receptor, as it does not produce a functioning protein and has no established role in pathology or therapeutic intervention[1][5]. In summary, IGKV1D-42 is a non-functional immunoglobulin variable gene within the human IGK locus, relevant mainly for immunogenetic annotation rather than as a molecular target for therapy or biomarker research[1][5][6].

Other names

Immunoglobulin kappa variable 1D-42IGKV1D-42Probable non-functional immunoglobulin kappa variable 1D-42IGKV1D42L22