Immunoglobulin kappa variable 1D-43 (IGKV1D-43)

Immunoglobulin kappa variable 1D-43 is a variable (V) region gene segment of the immunoglobulin kappa light chain locus involved in encoding the variable domain of immunoglobulin (antibody) light chains[1]. These variable domains contribute to the antigen binding site of antibodies, are generated by V-(D)-J rearrangement, and play central roles in the recognition phase of humoral immunity by B cells. IGKV1D-43 itself is not a therapeutic target, receptor, enzyme, or transporter, but represents one of the germline genes contributing to the diversity of antibody variable regions[1][3]. **Context and curation details:** - **IGKV1D-43** is a protein-coding gene segment residing in the *distal* V-gene cluster of the immunoglobulin kappa (IGK) locus at 2p11.2[1][3][5]. - It is not a druggable or conventional therapeutic target: it encodes part of the antibody variable region and functions as part of the adaptive immune response performed by B cell-produced immunoglobulins[1][3]. - **Aliases** are sourced from GeneCards; L23 and L23a are historical or alternative nomenclature[1]. - **Biological function:** Participates in forming the antigen recognition site of antibodies; plays a role in the generation of antigen specificity and affinity maturation by VJ rearrangement and somatic hypermutation[1][3]. - **Drug interactions, mechanisms, biomarkers, and safety concerns:** Not applicable since IGKV1D-43 is not targeted by drugs nor evaluated as a biomarker in patient selection or monitoring. It does not have adverse safety concerns as a gene product because it is not a protein drug or a therapeutic protein. - **Disease relevance:** Although variable regions like those encoded by IGKV1D-43 diversify immune responses and can be involved indirectly in autoimmunity or antibody-mediated diseases, IGKV1D-43 itself is not directly associated with a specific disease nor is it a disease driver or direct biomarker[1][3]. **Summary:** IGKV1D-43 is a germline immunoglobulin kappa variable region gene segment, essential in adaptive immunity for antibody diversity but not itself a recognized or actionable therapeutic target[1][3][5][4].

Other names

IGKV1D-43IGKV1D43L23L23a