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Target intelligence / Profile preview
Immunoglobulin kappa variable 1D-8 (IGKV1D-8)
- Target
- IGKV1D-8
- Molecular classification
- Immunoglobulin variable region, Immunoglobulin light chain variable domain, Other (component of antibody variable regions)
01
Overview
Immunoglobulin kappa variable 1D-8 is a protein component of the variable region of immunoglobulin kappa light chains, assembled by V-(D)-J gene rearrangement in B lymphocytes. It constitutes part of the antigen-binding site with its paired heavy chain, enabling antibodies to recognize a wide diversity of antigens. This region is critical for both membrane-bound and secreted immunoglobulins, forming the basis for humoral immune specificity and affinity maturation through somatic hypermutation. Aberrations in IGKV genes including IGKV1D-8 can be involved in lymphoid malignancies and autoimmunity, and their rearrangements are often used as molecular markers in diagnostics.
- Other names
- IGKV1D-8IGKV1D8L24L24aImmunoglobulin light chain variable regionimmunoglobulin kappa variable 1D-8
02
Biological functions
Antigen recognitionHumoral immune responseB cell receptor functionAntigen binding
03
Disease associations
Cancer (altered immunoglobulin expression in lymphomas/leukemias)Infection (adaptive immune response to pathogens)Autoimmune disease (autoantibody production)Other (antibody diversity in immunity)
04
Safety considerations
Possible involvement in autoimmunity if abnormal/autoantibody producedLymphoproliferative disorders (clonal expansions)
05
Biomarkers
Clonality markers for lymphoid malignancy (when used in clinical sequencing)Isotype patterns in immune profiling (research context)
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