Immunoglobulin kappa variable 2-24 (IGKV2-24)

Immunoglobulin kappa variable 2-24 (IGKV2-24) is a gene segment encoding the variable region of the kappa light chain in immunoglobulins (antibodies)[1][2][4][5][6]. This variable domain participates in antigen recognition and is generated by V-(D)-J recombination during B cell development, contributing to the diversity of antibodies in the adaptive immune system[2][5]. IGKV2-24 is not a stand-alone receptor, enzyme, or direct therapeutic target, but is a functional part of the antibody molecules either as membrane-bound B cell receptors or as secreted antibodies. Its main role is in forming the antigen-binding site in conjunction with immunoglobulin heavy chains, playing a central part in humoral immunity[2][4][5][6]. It is relevant in clinical immunology for evaluating B cell clonality and may be implicated in studies of immune repertoire or diagnostics but is not directly targeted by drugs[2][4][6].

Other names

IGKV2-24KV224A23IGKV224Immunoglobulin kappa chain V-II regionA0A0C4DH68