Immunoglobulin kappa variable 2-28 (IGKV2-28)

Immunoglobulin kappa variable 2-28 (IGKV2-28) is the variable region of the kappa light chain of immunoglobulins (antibodies)[1][2][8]. Its primary function is to contribute to the formation of the antigen-binding site of immunoglobulins, where it participates in recognizing and binding to specific antigens, forming part of the adaptive immune response[1][2][6]. This region undergoes V-(D)-J recombination and somatic hypermutation, processes that enable the immune system to generate a vast diversity of antibody specificities[2][6]. IGKV2-28 is one of many variable region genes that encode the immunoglobulin light chain's variable domain, essential for the specificity and affinity of antigen binding[2][6]. It is not considered a therapeutic target, receptor, enzyme, or classic disease biomarker, but rather a structural component of antibodies[2][5][8].

Other names

Immunoglobulin kappa variable 2-28IGKV2-28A19IGKV228