Immunoglobulin kappa variable 2-29 (IGKV2-29)

**Immunoglobulin kappa variable 2-29** (IGKV2-29) is the variable region of the kappa light chain of immunoglobulins (antibodies), involved in antigen recognition as part of the adaptive immune response. It encodes the variable domain that pairs with the variable domain of the heavy chain to form the antigen-binding site of an antibody. Through processes such as V-(D)-J rearrangement and somatic hypermutation, IGKV2-29 contributes to the diversity and affinity maturation of the antibody repertoire. This variable region is not itself a therapeutic target but is significant as one of many gene segments that generate antibody diversity essential for responding to pathogens[1][2][4][7]. **Notes and rationale:** - IGKV2-29 is a *gene segment* encoding part of the variable region of antibody light chains, not a receptor or classical drug target[2][4][7]. - No evidence that IGKV2-29 itself is a direct target for drugs or biomarker use[2][7]. - Some literature and aliases link the gene to responses to infections such as Haemophilus influenzae type b and SARS-CoV-2 by contributing to the antibody variable region's specificity[2][8]. - For "molecular_classifications", immunoglobulin variable regions do not fit into standard receptor, enzyme, transporter, or transcription factor classes—they are categorized as immunoglobulin variable regions ("Other"). - Some aliases overlap with processed antibody designations; only canonical gene/protein and major synonyms are listed. - No known safety concerns or established utility as a drug target, biomarker, or therapeutic challenge related specifically to the IGKV2-29 segment.

Other names

A18A18bIGKVIGKV229IGVK-A18IGKV2-29IGKV2D-29IG c1052_light_IGKV2D-29_IGKJ4IG c1152_light_IGKV2D-29_IGKJ4IG c1255_light_IGKV2D-29_IGKJ2IG c184_light_IGKV2D-29_IGKJ5IG c283_light_IGKV2D-29_IGKJ1IG c324_light_IGKV2D-29_IGKJ4IG c343_light_IGKV2D-29_IGKJ4IG c350_light_IGKV2D-29_IGKJ4IG c361_light_IGKV2D-29_IGKJ1IG c393_light_IGKV2D-29_IGKJ1IG c415_light_IGKV2D-29_IGKJ4IG c542_light_IGKV2D-29_IGKJ3IG c84_light_IGKV2D-29_IGKJ2IG c955_light_IGKV2D-29_IGKJ1IGVK A18banti-Hib capsular polysaccharide immunoglobulin light chain variable regionanti-SARS-CoV-2 RBD immunoglobulin light chain variable regionanti-SARS-CoV-2 immunoglobulin light chainantibody c103_light_IGKV2D-29_IGKJ5cross-reactive anti-SARS-CoV-2 immunoglobulin light chain variable regionimmunoglobulin heavy chain variable regionimmunoglobulin kappa light chain variable regionimmunoglobulin light chain variable regionimmunoglobulin light chain variable region BRA13