Immunoglobulin kappa variable 2-30 (IGKV2-30)

Immunoglobulin kappa variable 2-30 is a variable region gene segment encoding the variable domain of the kappa light chain of immunoglobulins (antibodies)[1]. The encoded region participates in antigen recognition by contributing to the antigen binding site of the antibody, pairing with heavy chain variable regions to confer specificity and diversity. This gene segment is expressed in B lymphocytes, where, after V-J rearrangement and possible somatic hypermutation, it helps generate the diverse antibody repertoire essential for humoral immunity. IGKV2-30 is part of the immunoglobulin kappa locus on chromosome 2 and is classified as a variable region gene (not a receptor, enzyme, or druggable therapeutic target). It is not itself a direct therapeutic target, drug target, or disease driver, but it contributes genetically and structurally to the antigen-binding properties of antibodies[1][3][4].

Other names

IGKV2-30IGKV230Ig kappa chain V-II region RPMI 6410A17