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Immunoglobulin kappa variable 2-40 (IGKV2-40)

Target: IGKV2-40
Molecular classification: Immunoglobulin variable domain, Immunoglobulin light chain component, Other (germline V gene segment)

Overview

Immunoglobulin kappa variable 2-40 (IGKV2-40) encodes the variable region segment of the kappa light chain in human antibodies[2][3]. Immunoglobulin light chains, along with heavy chains, form the antigen-binding domains of antibodies, crucial for immune recognition and response. Each B cell randomly assembles V (variable), J (joining), and C (constant) gene segments—such as IGKV2-40—via V(D)J recombination, generating high antibody diversity[2][3]. IGKV2-40 protein product is involved in antigen binding, forming part of the antigen-binding site in immunoglobulins[2][6]. Its expression as part of specific antibodies can be elevated during immune responses, but the segment itself is not a standalone therapeutic target nor directly modulated by drugs[2][6]. Alterations in its usage or expression may reflect immune status in some disease states[6].

Other names: IGKV2-40KV240O11O11aIg kappa chain V-II

Biological functions

Antigen bindingImmune response (humoral immunity)Formation of the antigen-binding site of antibodies

Disease associations

Other (dysregulation or aberrant usage may be indirectly relevant to diseases involving abnormal immune repertoires, e.g., autoimmune disorders or B cell malignancies, but there is no direct, disease-specific targeting)

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