Immunoglobulin kappa variable 2D-29 (IGKV2D-29)

Immunoglobulin kappa variable 2D-29 (IGKV2D-29) encodes the variable region of the kappa light chain of immunoglobulins (antibodies)[1][2][3][5]. This variable region is critical for the diversity of antibody antigen-binding through V(D)J recombination and somatic hypermutation, contributing to the adaptive immune response[3][5]. IGKV2D-29 is a component of the immunoglobulin gene family and plays an essential role in the recognition of foreign antigens by B cells[3][5]. The gene exhibits marked polymorphism and allele distribution that varies among human populations, potentially influencing susceptibility to certain infections such as Haemophilus influenzae type b[4]. There is no evidence indicating that IGKV2D-29 itself is a direct therapeutic or druggable target, receptor, enzyme, or transporter; rather, it is a genetic element contributing to antibody diversity[3][4][5].

Other names

A2AIGKV2D29A2C