Immunoglobulin kappa variable 2D-30 (IGKV2D-30)

Immunoglobulin kappa variable 2D-30 (IGKV2D-30) encodes the variable region of the kappa light chain of immunoglobulins (antibodies), which are glycoproteins produced by B lymphocytes[1][3][5][4]. The variable domain of this protein forms part of the antigen-binding site of antibodies, pairing with a heavy chain variable region to determine antigen specificity[1][7][3]. IGKV2D-30 is classified as a functional variable (V) gene within the distal cluster of the kappa light chain locus on chromosome 2p11.2[5][3]. Through V-J genomic rearrangement (a process known as V(D)J recombination), this segment combines with others to generate antibody diversity essential for adaptive immunity[1][3][8]. IGKV2D-30 itself is not a therapeutic target or disease driver; instead, it is part of the vast pool of antibody gene segments whose differential use affects immune repertoire diversity[1][5][3]. Variability at this locus can influence immune responses and has been implicated broadly in predisposition to infection, autoimmunity, and cancer through its role in antibody generation, but no direct drug interactions, biomarker status, or specific safety concerns are reported for this sequence itself[3][5][8].

Other names

IGKV2D-30Immunoglobulin kappa variable 2D-30IGKV2D30A1KV230KVD30