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Target intelligence / Profile preview
Immunoglobulin kappa variable 2D-40 (IGKV2D-40)
- Target
- IGKV2D-40
- Molecular classification
- Immunoglobulin variable region gene segment, Antibody light chain variable gene, Other (not a classic receptor/enzyme/transporter)
01
Overview
Immunoglobulin kappa variable 2D-40 is a protein-coding gene segment in the distal cluster of the IGK locus on chromosome 2 (2p11.2) that encodes the variable domain of kappa light chains in human antibodies[3]. Each immunoglobulin molecule consists of two heavy and two light chains (kappa or lambda), with the antigen-binding site formed through the pairing of heavy and light chain variable domains. The IGKV2D-40 gene contributes to antibody diversity via somatic recombination (V-J rearrangement) and hypermutation, which are central to the adaptive immune response. Its genetic variation influences the repertoire and affinity of antibodies produced by B lymphocytes[1][2][3]. It is not considered a drug target but is essential for basic immunological functions and diversity.
- Other names
- IGKV2D-40IGKV2D40Immunoglobulin kappa variable 2D-40Ig kappa chain V-II region CumO1
02
Mechanism of action
null
03
Biological functions
Antigen recognitionImmune responseFormation of antibody variable domains via V-(D)-J rearrangementAffinity maturation via somatic hypermutation
04
Disease associations
Other (Genetic variation may relate to immune function, antibody diversity, autoimmunity, or susceptibility to infections and some cancers)
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