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Immunoglobulin kappa variable 3-15 (IGKV3-15)
- Target
- IGKV3-15
- Molecular classification
- Immunoglobulin variable domain, Antibody light chain variable region, Other
01
Overview
Immunoglobulin kappa variable 3-15 is a variable domain segment of the kappa light chain in immunoglobulin (antibody) molecules, encoded by the IGKV3-15 gene. It participates in the formation of the antigen-binding site of antibodies, allowing specificity for a vast array of antigens via V(D)J recombination and somatic hypermutation. Its primary biological role is enabling antigen recognition, which is essential for the adaptive immune response by B lymphocytes. While the IGKV3-15 segment is an important contributor to antibody diversity, it is not considered a direct therapeutic target for drugs or biologics; rather, it is a component part of antibodies themselves. IGKV3-15 is not used clinically as a biomarker or therapeutic target.
- Other names
- IGKV3-15Ig kappa chain V-III region CLLIg kappa chain V-III region POMIGKV315L2Immunoglobulin kappa variable 3-15
02
Biological functions
Antigen bindingImmune response
03
Disease associations
Other (no direct disease association as a molecular target; immunoglobulin variable regions are studied in cancer, infection, autoimmunity, etc. but are not direct therapeutic targets)
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