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Target intelligence / Profile preview
Immunoglobulin kappa variable 3D-15 (IGKV3D-15)
- Target
- IGKV3D-15
- Molecular classification
- Immunoglobulin variable region gene, Immunoglobulin light chain V region, Other (gene segment of antibody light chain)
01
Overview
Immunoglobulin kappa variable 3D-15 (IGKV3D-15) encodes a variable domain of immunoglobulin kappa light chains, participating in antigen recognition as part of the B cell receptor and secreted antibodies. The variable region, formed via V-(D)-J rearrangement, enables high-affinity binding to diverse antigens and drives B cell clonal selection and response. Although the gene segment is critical for generating antibody diversity, IGKV3D-15 is not a receptor or enzyme directly amenable to therapeutic modulation. Its usage frequency and sequence characteristics can be relevant in studies of immune repertoire, especially in disorders like chronic lymphocytic leukemia, where certain IGKV gene segments are overrepresented[2][3][4].
- Other names
- IGKV3D-15IGKV3D15L16, L16a, L16b, L16cImmunoglobulin kappa variable 3D-15Immunoglobulin light chain variable region
02
Biological functions
Antigen recognitionImmune responseContribution to humoral immunity (through assembly of functional antibodies)
03
Disease associations
Cancer (not as direct driver, but usage/frequency of IGKV genes—such as IGKV3D-15—can be relevant in B cell malignancies like chronic lymphocytic leukemia; nonstochastic usage patterns noted in CLL)Other (role in autoimmune, infectious diseases through its contribution to antibody repertoire diversity)
04
Safety considerations
None reported specific to IGKV3D-15 as a drug targetSomatic hypermutation in immunoglobulin genes may occasionally contribute to immunopathology (autoimmunity, lymphoproliferative disorder), but IGKV3D-15 itself does not pose known direct safety risks.
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