Immunoglobulin kappa variable 3D-20 (IGKV3D-20)

Immunoglobulin kappa variable 3D-20 is the variable domain of the kappa light chain in human antibodies, encoded by the IGKV3D-20 gene. It contributes to the specificity and diversity of immunoglobulin molecules by participating in antigen recognition, forming part of the antigen-binding site along with heavy chain variable domains. The variable domains are generated by V-(D)-J recombination and somatic hypermutation processes during B cell development, enabling affinity maturation. This domain is integral to humoral immunity, as it enables B lymphocytes to generate antibodies capable of binding to a vast array of antigens, including pathogens and abnormal self molecules. While the diversity of immunoglobulin variable domains is crucial for immune response, IGKV3D-20 itself is not a direct therapeutic target; instead, it represents one of many immunoglobulin gene segments contributing to antibody repertoire[5][3][2][11].

Other names

IGKV3D-20Immunoglobulin kappa variable 3D-20A11A11aIGKV3D20KVD20 protein