Immunoglobulin kappa variable 6D-21 (IGKV6D-21)

Immunoglobulin kappa variable 6D-21 (IGKV6D-21) encodes the variable (V) region segment of the immunoglobulin kappa light chain, which participates in the formation of the antigen binding site of immunoglobulins (antibodies)[1][5]. This variable region is critical for the diversity and specificity of antibody-mediated antigen recognition; it is generated through V(D)J recombination as part of B cell development, enabling the immune system to recognize a wide array of pathogens[1]. IGKV6D-21 is a protein-coding gene, but it is catalogued as "non-functional" and participates as part of the immunoglobulin complex present in the plasma membrane and extracellular region[1][5]. It does not act as a therapeutic target (e.g., receptor/enzyme), nor is it directly targeted by drugs; its primary biological role is in antibody variability and immune defense rather than as an isolated actionable target[1][5].

Other names

IGKV6D-21IGKV6D21A10Immunoglobulin kappa variable 6D-21KVD21