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Immunoglobulin lambda variable (IV)-66-1 (IGLV(IV)-66-1)
- Target
- IGLV(IV)-66-1
- Molecular classification
- Immunoglobulin variable region, Pseudogene
01
Overview
Immunoglobulin lambda variable (IV)-66-1 is a pseudogene found in the human immunoglobulin lambda locus (IGL) on chromosome 22 (22q11.2). Unlike functional variable region genes, IGLV(IV)-66-1 does not produce a functional immunoglobulin light chain and is categorized among several IGLV pseudogenes (members of "clan IV"). Pseudogenes such as IGLV(IV)-66-1 have arisen from gene duplication and mutation events during the evolution of the immune gene loci. While functional immunoglobulin lambda variable genes are involved in generating antibody diversity, IGLV(IV)-66-1 does not encode a functional protein and has no direct role in immune function or disease beyond possible evolutionary genomic rearrangement.
- Other names
- IGLVIV-66-1IGLV(IV)-66-1Immunoglobulin lambda variable 66-1
02
Biological functions
No known function; non-functional gene segment in humans
03
Disease associations
No direct, known disease role; immunoglobulin variable pseudogenes may participate indirectly in antibody gene diversity through evolutionary mechanisms but do not encode proteins themselves
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