Immunoglobulin lambda variable 1-36 (IGLV1-36)

Immunoglobulin lambda variable 1-36 (IGLV1-36) is a protein-coding gene segment in the variable region of human immunoglobulin lambda light chains, located on chromosome 22. It encodes one of the multiple variant sequences B cells use to form the antigen-binding site of antibodies, critical for immune recognition and specificity. This gene undergoes V–J recombination in B lymphocyte development, pairing with joining (J) and constant (C) regions to produce functional antibodies. The variable domain encoded by IGLV1-36, when expressed as part of a complete immunoglobulin molecule, contributes to the diverse antibody repertoire required for effective immune response against pathogens and foreign antigens. However, as a germline gene segment, IGLV1-36 is not a direct therapeutic target itself but forms part of the broader antibody landscape essential for humoral immunity[2][6].

Other names

IGLV1-36Immunoglobulin lambda variable 1-36LV136V1-11IGLV136