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Immunoglobulin lambda variable 1-40 (IGLV1-40)
- Target
- IGLV1-40
- Molecular classification
- Immunoglobulin variable region gene, Antibody light chain variable domain segment, Other (component of adaptive immune system, not a classical receptor/enzyme)
01
Overview
Immunoglobulin lambda variable 1-40 is a variable region gene segment of the human immunoglobulin lambda light chain locus located on chromosome 22q11.2[1][5][6]. It encodes the variable domain of lambda light chains found in antibodies, which are critical for antigen recognition through the adaptive immune response. This gene undergoes somatic rearrangement and diversification, contributing to antibody specificity[2][4]. While essential for immune function and frequently studied in immunology research, it is not itself a direct drug target or receptor.
- Other names
- Ig lambda chain V-I region NEWMIGLV140V1-13Immunoglobulin lambda variable 1-40IGLV1-40V lambda A (some older literature)
02
Mechanism of action
Not applicable (NA); IGLV1-40 does not act as a drug target. Monoclonal antibodies engineered for therapeutic use may be constructed using human variable region sequences but are not considered "targeting" this gene[2][4].
03
Biological functions
Antigen recognitionImmune responseFormation of immunoglobulin diversity (through V(D)J recombination)
04
Disease associations
Cancer (e.g., certain lymphomas or leukemias involve rearrangements in immunoglobulin genes)Infection (key in generation of specific antibodies)Other (primary immunodeficiency if defective/rearranged)
05
Biomarkers
Potential use in clonality assessment in lymphoid malignancies (e.g. detection of monoclonal immunoglobulin rearrangements)Used in research for profiling the diversity of immune responses and antibody repertoires
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