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Target intelligence / Profile preview
Immunoglobulin lambda variable 1-44 (IGLV1-44)
- Target
- IGLV1-44
- Molecular classification
- Immunoglobulin variable region gene, Antigen-binding domain, Other (not a receptor, enzyme, transporter, or classic target)
01
Overview
Immunoglobulin lambda variable 1-44 (IGLV1-44) encodes the variable region of the lambda light chain in human antibodies[1][2][4][6]. This gene segment is involved in forming the antigen-binding site of antibodies as part of the somatic recombination process that generates antibody diversity[1][5]. IGLV1-44, as with other immunoglobulin variable region genes, contributes to B-cell receptor diversity, allowing the immune system to recognize a vast array of antigens. It is not a classical therapeutic target but is fundamental to the adaptive immune response and diagnostic assessments in B-cell disorders[1][5][6].
- Other names
- Ig lambda chain V-I region MEMIg lambda chain V-I region VORIGLV144V1-16Immunoglobulin lambda variable 1-44IGLV1-44
02
Biological functions
Antigen bindingAdaptive immune responseHumoral immunity
03
Disease associations
Cancer (e.g., clonal rearrangements in lymphoma/leukemia)Immune dysregulation (context-dependent; not directly pathogenic themselves)
04
Biomarkers
Immunoglobulin gene rearrangement (used in lymphoma/leukemia clonality testing, B-cell malignancy monitoring)
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