Immunoglobulin lambda variable 1-47 (IGLV1-47)

Immunoglobulin lambda variable 1-47 is one of the several germline gene segments encoding the variable domain of immunoglobulin lambda light chains. This region is critical for antigen recognition and diversity in antibodies produced by B cells. Immunoglobulins mediate the humoral phase of the immune response, with the variable region enabling specific binding to pathogens. The diversity of antibody specificity arises from the recombination and mutation of variable domains like IGLV1-47, which, alongside its associated heavy chain, forms the antigen recognition epitope. This gene is located on chromosome 22 and is typically expressed in blood microparticles derived from B cells. IGLV1-47 is chiefly a genetic segment for immunoglobulin variability, and not a conventional molecular target for drug therapeutics.

Other names

Immunoglobulin lambda variable 1-47IGLV1-47Ig lambda chain V-I region HAIg lambda chain V-I region WAHIGLV147V1-17

Not applicable