Immunoglobulin lambda variable 11-55 (IGLV11-55)

Immunoglobulin lambda variable 11-55 (IGLV11-55) is a variable region gene segment of the human immunoglobulin lambda light chain locus, located on chromosome 22q11.2[3]. It is classified as a probable "non-functional open reading frame" (ORF), meaning that it generally cannot participate in the synthesis of a productive immunoglobulin light chain due to recombination defects, splicing errors, or conserved amino acid changes[1][3]. Immunoglobulins normally serve as receptors on B lymphocytes or as secreted antibodies in humoral immunity, but non-functional variable regions such as IGLV11-55 do not contribute to these processes[1][3]. The locus itself contains dozens of variable region genes, pseudogenes, and orphons that together expand immunoglobulin diversity but only a subset are functional[3]. IGLV11-55 is catalogued in immunogenetics databases due to gene mapping efforts, but has no evidence of direct biological or therapeutic relevance.

Other names

IGLV11-55Probable non-functional immunoglobulin lambda variable 11-55IGLV1155V4-6LVK55

Null; no mechanism established for drug targeting