Immunoglobulin lambda variable 2-28 (pseudogene) (IGLV2-28)

Immunoglobulin lambda variable 2-28 (abbreviated as IGLV2-28 or aliases IGLV228, V1-8P) is classified as a pseudogene in the human genome[5][6][8]. Pseudogenes resemble normal genes but are non-functional due to mutations or deletions, and they do not encode a functional protein. IGLV2-28 is related to the variable region of immunoglobulin lambda light chains, which are components of antibodies produced by B lymphocytes, but the IGLV2-28 sequence is non-functional and does not contribute to antibody production or immune recognition[1][5]. As a pseudogene, it is not considered a therapeutic target, does not have known disease roles, and is not involved in biological processes typically associated with protein-coding immunoglobulin variable genes. Therefore, it is generally not of direct clinical or therapeutic significance. Notes: - Multiple authoritative databases (GeneCards, Merck Millipore) classify IGLV2-28 as a pseudogene[5][6][8]. - It does not encode a protein and has no established roles as a biomarker or drug target. - No drugs, disease associations, or biological activities are reported. If a protein-coding immunoglobulin lambda variable gene is intended, the query should be revised, as IGLV2-28 is specifically non-coding and non-functional in humans[5][8].

Other names

IGLV228V1-8PIGLV2-28