Immunoglobulin lambda variable 3-16 (IGLV3-16)

Immunoglobulin lambda variable 3-16 (IGLV3-16) encodes the variable region of the lambda light chain of immunoglobulins, which are essential components of antibodies produced by B cells[1][3][4][5][7]. The variable domain participates in the recognition and binding of antigens, forming the antigen-binding site together with the variable domain of the heavy chain[3][4][7]. This process is fundamental for the adaptive immune response and the effector phase of humoral immunity—where secreted immunoglobulins mediate elimination of bound antigens[6]. IGLV3-16 is predicted to be located in the extracellular region and the plasma membrane, as part of the immunoglobulin complex[1][5]. While its gene is catalogued with known structure and expression, IGLV3-16 represents a segment of antibody diversity and is not by itself considered a therapeutic target such as a receptor, enzyme, or transporter. Instead, its functional relevance relates to antigen specificity in the overall antibody repertoire[1][5][7]. No direct evidence supports a role as a drug target or associations with interacting drugs, mechanism of action, biomarker utility, or specific safety concerns. It should be classified primarily as part of the immunoglobulin gene family, with well-documented molecular biology and immunological function.

Other names

IGLV3-16IGLV316V2-11