Immunoglobulin lambda variable 3-30 (IGLV3-30)

Immunoglobulin lambda variable 3-30 (IGLV3-30) is a gene that encodes the variable region of the lambda light chain in human antibodies. Immunoglobulin variable regions create the diversity of binding sites necessary for antibody-mediated recognition of foreign antigens. The IGLV3-30 gene is part of the immunoglobulin lambda (IGL) locus on chromosome 22 and contributes to the repertoire of antibody specificities via V-J recombination and somatic hypermutation. It does not function as a classical drug target such as a receptor, enzyme, or transporter, but forms part of secreted or membrane-bound immunoglobulins expressed by B-cells in the adaptive immune system. While immunoglobulin light chains—including lambda types—can be overexpressed in certain hematological malignancies (e.g., multiple myeloma), IGLV3-30 itself is not a direct therapeutic target and is not specifically associated with targeted drugs or therapies. If you need further detail on the broader immunoglobulin light chain family, or associated pathologies, or wish for information on the functional antibody molecule as a drug target (e.g., CD20 receptor or immunoglobulin Fc regions), clarification can be provided.

Other names

IGLV3-30Immunoglobulin lambda variable region 3-30Ig lambda V3-30

Not applicable; not a direct therapeutic target. The variable region is involved in antigen recognition as part of antibody molecules.