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Immunoglobulin lambda variable 3-6 (IGLV3-6)
- Target
- IGLV3-6
- Molecular classification
- Immunoglobulin variable region, Antibody variable domain, Other
01
Overview
Immunoglobulin lambda variable 3-6 (IGLV3-6) is a gene segment that encodes the variable region of the lambda light chain in immunoglobulins (antibodies)[2][4]. The variable region is a critical component of the antigen-binding site, formed through V(D)J recombination in B cells, conferring specificity to the adaptive immune response[2]. IGLV3-6 is one of several members of the IGLV3 gene family that contribute to the diversity of the antibody repertoire by recombining with different joining segments and undergoing somatic hypermutation. The variable domain is expressed as part of the light chain either on the surface of B cell receptors or in secreted antibodies[2]. While essential for immune function, IGLV3-6 itself is not considered a therapeutic target but rather a genetic building block for antibody diversity[1][2][4].
- Other names
- IGLV36V2-4PIGLV3-6
02
Biological functions
Antigen recognitionAdaptive immune response
03
Disease associations
Other (Immunoglobulin gene segment diversity is related to immunity and possibly to susceptibility/resistance to infection; not a direct or canonical drug target in disease)
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