Immunoglobulin lambda variable 3-7 (IGLV3-7)

Immunoglobulin lambda variable 3-7 is a gene encoding one of the variable domains of the immunoglobulin lambda light chain. This gene is located in the immunoglobulin lambda locus on chromosome 22q11.2 and encodes a segment that contributes to the antigen-binding site through V(D)J recombination in B cells. The lambda light chains are one of two types of immunoglobulin light chains in humans (the other being kappa), and their variable domains provide sequence diversity essential for the adaptive immune response. The IGLV3-7 gene, along with other IGLV genes, is part of a complex locus exhibiting high allelic variation, reflecting evolutionary adaptation to pathogens. IGLV3-7 is not a classical drug target, receptor, or enzyme—rather, it is a genomic element contributing to antibody diversity. Its role and importance are primarily within the scope of immunogenetics and antibody structure, rather than as a molecule intended for direct pharmacological modulation.

Other names

IGLV37V2-5PIGLV3-7

Not applicable (does not serve as a target for drugs or antibodies; its gene products are incorporated into the antigen recognition site of antibodies)