Immunoglobulin lambda variable 3-9 (IGLV3-9)

Immunoglobulin lambda variable 3-9 (IGLV3-9) is a gene encoding a variable domain of the lambda light chain of human immunoglobulins (antibodies), participating in antigen recognition as part of the immunoglobulin complex[1][3][5]. The protein product is a component of the antigen binding site, formed together with the variable domain of an immunoglobulin heavy chain, conferring antigen specificity to the antibody[3][1][5]. This gene is expressed in B lymphocytes and contributes to the immune system’s ability to recognize and respond to a diverse array of antigens. While IGLV3-9 plays a pivotal role in adaptive immunity, it is not itself a classical therapeutic target (such as a receptor, transporter, enzyme) but rather part of the broader antibody repertoire[1][3][5]. Variants or alterations in immunoglobulin variable genes, including IGLV3-9, have been reported in some studies associating immunoglobulin repertoire diversity with susceptibility to disease, including immune dysregulation or neurodevelopmental disorders[1].

Other names

Immunoglobulin lambda variable 3-9IGLV3-9IGLV39V2-6LV39