Immunoglobulin lambda variable 4-3 (IGLV4-3)

Immunoglobulin lambda variable 4-3 is a **variable domain segment** of the immunoglobulin (antibody) light chain, specifically the lambda light chain family, subgroup 4-3. This segment is part of the V (variable) region, which is essential for **antigen recognition** as a component of the immunoglobulin molecule. During B-cell development, variable domains like IGLV4-3 undergo recombination and contribute to the generation of immunoglobulin diversity by pairing with a joining (J) segment and a constant (C) segment, resulting in a mature light chain that combines with a heavy chain. The binding site for antigens is constructed from the variable regions of both the immunoglobulin heavy and light chains, giving rise to antibody specificity[1][3]. IGLV4-3 participates in the recognition phase of the humoral immune response; membrane-bound immunoglobulins serve as B-cell receptors, while secreted forms mediate effector functions through antigen binding and elimination. The gene is located on chromosome 22q11.2 and is one of many genes that encode variable regions for the lambda light chain locus[5]. IGLV4-3 is not a therapeutic target, receptor, or enzyme in the conventional sense, but it is essential to the molecular structure and function of antibodies in adaptive immunity[1][3].

Other names

IGLV4-3IGLV43V5-1