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Immunoglobulin lambda variable 5-45 (IGLV5-45)
- Target
- IGLV5-45
- Molecular classification
- Other (immunoglobulin variable region gene segment), Immunoglobulin variable region, Antibody variable domain
01
Overview
Immunoglobulin lambda variable 5-45 is a gene segment encoding the variable (V) domain of the light chain in antibodies. This domain participates in the formation of the antigen-binding site, together with the variable domain from the heavy chain, enabling antibodies to recognize a wide array of antigens. The immunoglobulin variable region genes undergo V-(D)-J rearrangement and somatic hypermutation, generating antibody diversity vital for humoral immunity. IGLV5-45 resides in the immunoglobulin lambda locus on chromosome 22 (22q11.2) and is expressed in B lymphocytes[1][2][4][5][7][8]. While essential for immune recognition, it is not considered a conventional therapeutic target, receptor, enzyme, or transporter.
- Other names
- Immunoglobulin lambda variable 5-45IGLV5-45IGLV545V4-2
02
Biological functions
Antigen recognitionAdaptive immune response (humoral immunity)Generation of antibody diversity via V-(D)-J rearrangement and somatic hypermutation
03
Disease associations
Other (no direct disease association as a target, but rearrangements or mutations in immunoglobulin variable genes may play a role in lymphoid malignancies such as lymphoma; these roles typically concern clonal selection or somatic mutation rather than direct targeting)
04
Biomarkers
Other (in some hematological malignancies, the clonal usage of specific immunoglobulin variable genes may serve as a biomarker for clonality or disease monitoring, but IGLV5-45 is not commonly used for this purpose)
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