Immunoglobulin lambda variable 6-57 (IGLV6-57)

Immunoglobulin lambda variable 6-57 (IGLV6-57) is a variable region gene segment of the lambda light chain locus in human immunoglobulins. It encodes the variable (V) domain of lambda light chains, which combine with heavy chain variable domains to form the antigen-binding site of antibodies. V-region segments undergo recombination and hypermutation to provide antibody diversity. IGLV6-57-derived light chains are expressed in a minority of plasma cells, but are overrepresented in pathological monoclonal light chain production, especially in AL amyloidosis, where they are prone to misfolding and aggregation into amyloid fibrils. IGLV6-57 variable domains play a specific structural and physicochemical role in amyloid fibril formation, and their sequence features affect susceptibility to pathogenic aggregation[2][4]. IGLV6-57 is not a conventional therapeutic target like a receptor or enzyme, but its sequence and products are important as biomarkers in amyloidosis and for understanding antibody diversity[2][4][3].

Other names

Immunoglobulin lambda variable 6-57IGLV6-57Ig lambda chain V-VI region ARIg lambda chain V-VI region EB4Ig lambda chain V-VI region NIG-48Ig lambda chain V-VI region SUTIg lambda chain V-VI region WLTIGLV657V1-22amyloid lambda 6 light chain variable region PIPamyloid lambda 6 light chain variable region SAR