Immunoglobulin lambda variable 9-49 (IGLV9-49)

Immunoglobulin lambda variable 9-49 (IGLV9-49) encodes the variable region of the lambda light chain of immunoglobulins, which are antibodies produced by B lymphocytes as part of the adaptive immune response[1][3][5]. The variable region determines antigen specificity by forming part of the antigen binding site along with the immunoglobulin heavy chain variable region, enabling the recognition and binding of diverse antigens[1][3]. IGLV9-49 is not itself a receptor or therapeutic target but represents one of many variable (V) gene segments that undergo somatic recombination (V-(D)-J rearrangement) to generate antibody diversity in humans[1][2][3]. It is a structural component necessary for the broad specificity of antibody-mediated immunity and is classified as an immunoglobulin variable domain gene localized on human chromosome 22q11.2[2][4]. It has no direct interactions with drugs and is not considered a biomarker or cause of adverse safety issues[1][3][5].

Other names

Immunoglobulin lambda variable 9-49IGLV9-49IGLV949V5-2